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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Glutamate--cysteine ligase regulatory subunit |
Synonyms: | GCS light chain, Gamma-ECS regulatory subunit, Gamma-glutamylcysteine synthetase regulatory subunit, Gclm, Glclr |
Immunogen: | Recombinant protein corresponding to Mouse GCLM |
Uniprot ID: | O09172 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 31 kDa / 31 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | liver, spleen, heart |
Background
GCLM(Glutamate--cysteine ligase regulatory subunit) is also named as GLCLR and belongs to the aldo/keto reductase family. It catalyzes the first step of GSH synthesis and is involved in gamma-glutamyl cycle. GCLM is implicated in some forms of hemolytic anemia.Gamma-glutamylcysteine synthetase (gamma-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant.
Images
| Western blot analysis of GCLM (GB111827) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
