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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ubiquitin-like protein 4A |
Synonyms: | DX254E, DXS254E, G6PD, GDX, ubiquitin like 4A, Ubiquitin like protein 4A, Ubiquitin like protein GDX, UBL4, UBL4A |
Immunogen: | Recombinant protein corresponding to Mouse UBL4A |
Uniprot ID: | P21126 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Product Usage Information
IHC/IF | Human | 1: 900-1: 1800 | colon cancer, gastric carcinoma, liver cancer |
Background
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum.
Images
| Immunohistochemistry analysis of paraffin embedded human colon cancer using UBL4A (GB114456) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded human gastric carcinoma using UBL4A (GB114456) at dilution of 1: 900 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using UBL4A (GB114456) at dilution of 1: 900 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
