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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | GM2A rabbit polyclonal antibody |
Gene Name: | Ganglioside GM2 activator |
Synonyms: | Cerebroside sulfate activator protein, GM2-AP, Sphingolipid activator protein 3, SAP-3, Gm2a, GM2 ganglioside activator, Ganglioside GM2 activator precursor |
Immunogen: | Recombinant protein corresponding to Mouse GM2A |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Lysosome |
Predicted MW. | 21 kDa |
Observed MW. | 17 kDa |
Uniprot ID: | Q60648 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1:500-1:1000 | liver, kidney, skin |
IHC/IF | Mouse, Rat | 1:1000-1:2000 | kidney, liver |
Background
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
Images
| Western blot analysis of GM2a (GB112121) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded mouse kidney using GM2a (GB112121) at dilution of 1: 1000 (300x lens) |
| Immunohistochemistry of paraffin embedded mouse liver using GM2a (GB112121) at dilution of 1: 1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using GM2a (GB112121) at dilution of 1: 1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat liver using GM2a (GB112121) at dilution of 1: 1000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse kidney using GM2a (GB112121) at dilution of 1: 1000 (400x lens) |
| Immunofluorescence of paraffin embedded rat liver using GM2a (GB112121) at dilution of 1: 1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
