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Anti-GSK3 beta Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK3B, Gsk3b, 7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3, glycogen synthase kinase 3 beta |
Immunogen: | Recombinant protein corresponding to Mouse GSK3 beta |
Uniprot ID: | Q9WV60 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 47 kDa / 47 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, heart, lung |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1000 | testis, stomach, brain |
Background
Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase .GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.In skeletal muscle, it contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Researches showed that the crystal structure of human GSK3B, expressed in insect cells, at 2.8-angstrom resolution .This antibody recognize the C-terminal of GSK3B.
Images
| Western blot analysis of GSK3 beta (GB111694) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using GSK3B (GB111694) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded mouse brain using GSK3B (GB111694) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
