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Recombinant Anti-Granzyme B Mouse mAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Granzyme B |
Synonyms: | CCPI, CGL 1, CGL1, CSP B, CSPB, CTLA1, CTSGL1, Endogenous granzyme B, Granzyme B, GZMB, HLP, SECT |
Immunogen: | Human recombinant Granzyme B protein expressed in HEK293 cells |
Uniprot ID: | P10144 |
Isotype: | IgG1 |
Purity: | Affinity purification |
Subcellular location: | Cytoplasmic granule |
Predicted MW. / Observed MW. | 28 kDa / 30 kDa |
Product Usage Information
IHC/IF | Rat | 1: 500-1: 1000 | Inflammatory model induced by lps(6h) liver, model of antigen stimulation lung |
Background
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp . Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death .
Images
| IHC analysis of Granzyme B(GB15093). |
| IHC analysis of Granzyme B(GB15093). Sample: Rat model of antigen stimulation lung, 4% PFA (G1101) 12-24h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
