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Anti-HDAC1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Histone deacetylase 1 |
Synonyms: | HD1, HDAC1, RPD3L1, RPD3, Reduced potassium dependency yeast homolog like 1, GON 10 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human HDAC1 |
Uniprot ID: | Q13547 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 55 kDa / 62 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 600 | testis, stomach, colon |
IHC/IF | Human, Mouse, Rat | 1: 300-1: 600 | breast cancer, brain, stomach |
Background
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Images
| Western blot analysis of HDAC1 (GB112052) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using HDAC1 (GB112052) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded rat brain using HDAC1 (GB112052) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
