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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HES5 rabbit polyclonal antibody |
Gene Name: | Transcription factor HES-5 |
Synonyms: | Hairy and enhancer of split 5, Hes5, bHLHb38, Class B basic helix-loop-helix protein 38, Hairy and enhancer of split 5, hes family bHLH transcription factor 5 |
Immunogen: | Recombinant protein corresponding to Mouse HES5 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 18 kDa |
Observed MW. | 18 kDa |
Uniprot ID: | P70120, Q03062 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | kidney, liver, brain, embryo |
Background
Hairy and Enhancer-of-split homologues 5 (HES5) is a helix-loop-helix transcriptional factor that negatively regulates cell differentiation during embryogenesis. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. HES5 as a transcriptional repressor of genes that require a bHLH protein for their transcription and plays an important role as neurogenesis negative regulator. HES5 is reported to be a down stream effector of the Notch Signaling Pathway and is expressed in advanced ovarian serous adenocarcinomas as well as in cervical squamous carcinoma.
Images
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Western blot analysis of Hes5 (GB111398) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |