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Anti-HIF3 alpha/IPAS Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HIF3 alpha rabbit polyclonal antibody |
Gene Name: | Hypoxia-inducible factor 3-alpha |
Synonyms: | HIF3-alpha, bHLHe17, HIF3-alpha-1, PASD7, IPAS, Member of PAS protein 7, BHLHE17, HIF3A, MOP7 |
Immunogen: | Recombinant protein corresponding to Mouse HIF3 alpha |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q9Y2N7 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 800-1: 3000 | kidney, liver, lung |
Background
Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis.
Images
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Immunohistochemistry of paraffin embedded mouse kidney using HIF-3α (GB111175) at dilution of 1:1600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse liver using HIF-3α (GB111175) at dilution of 1:1600 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using HIF-3α (GB111175) at dilution of 1:1600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
