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Anti-HLA-DR Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | HLA class II histocompatibility antigen, DR alpha chain |
Synonyms: | HLA DRA, HLA DRA1, HLA-DR, HLA-DRA, MHC class II antigen DRA |
Immunogen: | Recombinant protein corresponding Human HLA-DRA |
Uniprot ID: | P01903 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 29 kDa / 34 kDa |
Product Usage Information
WB | Human | 1: 500-1: 2000 | U87 |
Background
An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins.
Images
| WB analysis of HLA-DR(GB115643). Sample: Protein treated by RIPA Lysis Buffer (G2002). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
