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Anti-HMGB2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | High mobility group protein B2 |
Synonyms: | high mobility group box 2, High mobility group protein 2, HMG-2, HMG2, HMGB2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HMGB2 |
Uniprot ID: | P30681 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Chromosome, Cytoplasm, Nucleus, Secreted |
Predicted MW. / Observed MW. | 24 kDa / 24 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | spleen, testis |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | spleen, testis, duodenum |
Background
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
Images
| Western blot analysis of HMGB2 (GB113839) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin-embedded mouse spleen using HMGB2 (GB113839) at dilution of 1: 2000 |
 | Immunohistochemistry analysis of paraffin-embedded mouse testis using HMGB2 (GB113839) at dilution of 1: 2000 |
 | Immunohistochemistry analysis of paraffin-embedded rat testis using HMGB2 (GB113839) at dilution of 1: 2000 |
 | Immunohistochemistry analysis of paraffin-embedded rat duodenum using HMGB2 (GB113839) at dilution of 1: 2000 |
 | Immunofluorescent analysis of paraformaldehyde-fixed mouse testis using HMGB2 (GB113839) at dilution of 1: 2000 |
 | Immunofluorescent analysis of paraformaldehyde-fixed rat testis using HMGB2 (GB113839) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
