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Anti-HP1 alpha Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HP1 alpha rabbit polyclonal antibody |
Gene Name: | Chromobox protein homolog 5 |
Synonyms: | CBX5, HEL25, HP1, HP1A, chromobox 5 |
Immunogen: | Recombinant protein corresponding to Mouse HP1 alpha |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 22 kDa |
Observed MW. | 22 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1:500-1:1000 | brain, kidney, testis |
IHC/IF | Human, Mouse, Rat | 1:500-1:2000 | brain, breast cancer, gall bladder, placenta, thyroid gland |
Background
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called (in humans) HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins.
Images
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Western blot analysis of hp1 (GB11609) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded human breast cancer using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human breast cancer using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse brain using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
 | Immunofluorescence of paraffin embedded human thyroid gland using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse placenta using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat gall bladder using HP1 alpha (GB11609) at dilution of 1: 1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
