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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | HSF1 rabbit polyclonal antibody |
Gene Name: | Heat shock factor protein 1 |
Synonyms: | Hsf1, HSF1, HSTF1, Heat shock transcription factor 1 |
Immunogen: | Recombinant protein corresponding to Mouse HSF1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q00613, P38532 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 250-1: 2000 | skeletal muscle, stomach, testis, tumor |
Background
The HSF1 protein regulates the heat shock response (HSR) pathway in humans by acting as the major transcription factor for heat shock proteins. The HSR plays a protective role by ensuring proper folding and distribution of proteins within cells. This pathway is induced by not only temperature stress, but also by a variety of other stressors such as hypoxic conditions and exposure to contaminants. HSF1 transactivates genes for many cytoprotective proteins involved in heat shock, DNA damage repair, and metabolism.
Images
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Immunohistochemistry of paraffin embedded rat testis using hsf1 (GB11932) at dilution of 1:2400 (250x lens) |
 | Immunohistochemistry of paraffin embedded rat tumor using hsf1 (GB11932) at dilution of 1:1200 (300x lens) |
 | Immunofluorescence of paraffin embedded human stomach using hsf1 (GB11932) at dilution of 1:500 (250x lens) |
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Immunofluorescence of paraffin embedded mouse Skeletal muscle using hsf1 (GB11932) at dilution of 1:500 (300x lens) |
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Immunofluorescence of paraffin embedded rat Skeletal muscle using hsf1 (GB11932) at dilution of 1:500 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |