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Anti-Histidase Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Histidine ammonia-lyase |
Synonyms: | HAL, HIS, HSTD |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse HAL |
Uniprot ID: | P35492 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 72 kDa / 72 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 2000-1: 3000 | liver |
Background
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Images
| Western blot analysis of HAL (GB115158) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
