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| Reactivity: | M & R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Inhibitor of Bruton tyrosine kinase |
Synonyms: | BTBD26, BTKI, DKFZP564B116 |
Immunogen: | Recombinant protein corresponding to Mouse IBTK |
Uniprot ID: | Q6ZPR6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Membrane |
Predicted MW. / Observed MW. | 150 kDa / 150 kDa |
Product Usage Information
WB | Mouse | 1: 300-1: 500 | skeletal muscle |
IHC/IF | Rat | 1: 800-1: 1600 | lymph node, thymus gland |
Background
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity).
Images
| Western blot analysis of IBTK (GB114533) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded rat lymph node using IBTK (GB114533) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded rat thymus gland using IBTK (GB114533) at dilution of 1: 800 |
| Immunofluorescence analysis of paraffin embedded rat spleen using IBTK (GB114533) at dilution of 1: 800 |
| Immunofluorescence analysis of paraffin embedded rat thymus gland using IBTK (GB114533) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
