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Anti-IFIT5 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IFIT5 rabbit polyclonal antibody |
Gene Name: | Interferon-induced protein with tetratricopeptide repeats 5 |
Synonyms: | IFIT-5, Interferon-induced 58 kDa protein, Retinoic acid- and interferon-inducible 58 kDa protein, P58, IFIT5, ISG58, RI58 |
Immunogen: | Recombinant protein corresponding to Human IFIT5 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Uniprot ID: | Q13325 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse | 1: 300-1: 1800 | colon cancer, embryonic mouse, tonsil |
Background
Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.
Images
| Immunohistochemistry of paraffin embedded human colon cancer using IFIT5 (GB111810) at dilution of 1:500 (200x lens) |
| Immunohistochemistry of paraffin embedded human tonsil using IFIT5 (GB111810) at dilution of 1:500 (300x lens) |
| Immunohistochemistry of paraffin embedded mouse embryonic mouse using IFIT5 (GB111810) at dilution of 1:300 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
