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Anti-IKK beta Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
Synonyms: | I kappa B kinase 2, I kappa B kinase beta, IKBKB, IKK B, IKK beta, IKK2, IKKB, IκB, NFKBIKB |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IKK beta |
Uniprot ID: | O88351 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus, Membrane |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 100-1: 200 | heart, kidney |
Background
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.
Images
| IHC analysis of IKKβ (GB115540). |
| IHC analysis of IKKβ (GB115540). |
| IHC analysis of IKKβ (GB115540). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
