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| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Interleukin-10 |
Synonyms: | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IL-10 |
Uniprot ID: | P22301, P29456 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Product Usage Information
IHC/IF | Rat | 1: 500-1: 2000 | lung, pneumonia |
Background
IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway.
Images
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Immunohistochemistry analysis of paraffin-embedded rat lung using IL-10 (GB12108) at dilution of 1: 2000. |
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Immunohistochemistry analysis of paraffin-embedded rat pneumonia using IL-10 (GB12108) at dilution of 1: 1000. |
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Immunofluorescence analysis of paraffin-embedded mouse Inflammatory lung using IL-10 (GB12108) at dilution of 1:300. |
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Immunofluorescence analysis of paraffin-embedded rat Inflammatory lung using IL-10 (GB12108) at dilution of 1:600. |
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Immunofluorescence analysis of paraffin-embedded rat Inflammatory spleen using IL-10 (GB12108) at dilution of 1:600. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
