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Anti-IL-1R-2 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IL-1R-2 rabbit polyclonal |
Gene Name: | Interleukin-1 receptor type 2 |
Synonyms: | IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2, IL1 Receptor II |
Immunogen: | Recombinant protein corresponding to Mouse IL1 Receptor II |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, Cell membrane |
Uniprot ID: | P27931 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 300-1: 600 | pneumonia, spleen |
IF | Mouse, Rat | 1: 100-1: 300 | pneumonia, spleen |
Background
The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signalling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse pneumonia using IL1 Receptor II (GB11603) at dilution of 1: 300 |
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using IL1 Receptor II (GB11603) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
