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Anti-IL-34 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | IL-34 rabbit polyclonal antibody |
Gene Name: | Interleukin-34 |
Synonyms: | IL-34, Chromosome 16 open reading frame 77 , C16orf77, FPT025 |
Immunogen: | Recombinant protein corresponding to Mouse IL-34 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: | Q8R1R4, Q4KM46 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 1500 | colon, heart |
Background
IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
Images
| Immunohistochemistry of paraffin embedded mouse colon using IL34 (GB111855) at dilution of 1:900 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse heart using IL34 (GB111855) at dilution of 1:900 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
