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Anti-ITGB6 Rabbit pAb (100 μl)
| Reactivity: | R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Integrin beta-6 |
Synonyms: | Integrin beta 6 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ITGB6 |
Uniprot ID: | Q9Z0T9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane, Cell junction |
Predicted MW. / Observed MW. | 86 kDa / 86 kDa |
Product Usage Information
WB | Rat | 1: 300-1: 500 | brain |
IHC/IF | Human, Mouse, Rat | 1: 600-1: 1800 | colon cancer, kidney |
Background
Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.
Images
| Western blot analysis of Itgb6 (GB114885) at dilution of 1:500 |
| Immunohistochemistry of paraffin embedded human colon cancer using Itgb6 (GB114885) at dilution of 1: 600 |
| Immunohistochemistry of paraffin embedded rat kidney using Itgb6 (GB114885) at dilution of 1: 600 |
| Immunohistochemistry of paraffin embedded mouse kidney using Itgb6 (GB114885) at dilution of 1: 600 |
| Immunohistochemistry of paraffin embedded human kidney using Itgb6 (GB114885) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
