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Anti-Inhibin alpha Rabbit pAb (100 μl)
| Reactivity: | M & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Inhibin alpha rabbit polyclonal antibody |
Gene Name: | Inhibin alpha chain |
Synonyms: | INHA, Inhibin alpha subunit, inhibin subunit alpha, A inhibin subunit precursor, IHA, Inhibin alpha chain, Inhibin alpha chain precursor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Inhibin alpha |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. | 40 kDa |
Observed MW. | 40 kDa |
Uniprot ID: | Q04997 |
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Applications
Applications | Species | Dilution | Positive Sample |
WB | Mouse | 1: 500-1: 1000 | testis, brain |
IHC/IF | Human | 1: 500-1: 1600 | breast cancer, colon |
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Background
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells.
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Images
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Western blot analysis of Inhibin Alpha (GB11741) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded human breast cancer using Inhibin Alpha (GB11741) at dilution of 1: 800 (400x lens) |
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Immunohistochemistry of paraffin embedded human colon using Inhibin Alpha (GB11741) at dilution of 1: 800 (400x lens) |
Storage
>| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
