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Anti-Integrin beta 3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Integrin beta-3 |
Synonyms: | Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Integrin beta 3 |
Uniprot ID: | P05106 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 87 kDa / 100 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | spleen, thymus, lung |
IHC/IF | Mouse, Rat | 1: 1000-1: 2000 | bone, spleen |
Background
Integrin beta-3, also named as CD61 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin beta-3 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
Images
| Western blot analysis of Integrin beta 3 (GB112253) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse spleen using Integrin β3 (GB112253) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat bone using Integrin β3 (GB112253) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
