Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | JNK3 rabbit polyclonal antibody |
Gene Name: | Mitogen-activated protein kinase 10 |
Synonyms: | JNK3, MAPK10, JNK3A, PRKM10, SAPK1b, Mitogen-activated protein kinase 10 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse JNK3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 53 kDa |
Observed MW. | 53 kDa |
Uniprot ID: | Q61831, P53779, P49187 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, cerebellum, spinal cord |
Background
MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
Images
 |
Western blot analysis of JNK3 (GB11846) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
