Your shopping cart is empty!
| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | KCC2 rabbit polyclonal |
Gene Name: | Solute carrier family 12 member 5 |
Synonyms: | hKCC2, KCC2, KIAA1176, Neuronal K-Cl cotransporter, SLC12A5, Electroneutral potassium-chloride cotransporter 2, K-Cl cotransporter 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse KCC2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 900-1: 1800 | brain, spinal cord |
Background
KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl- cotransporter that is essential for Cl- homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse brain using KCC2 (GB113707) at dilution of 1: 1800 |
| Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using KCC2 (GB113707) at dilution of 1: 1800 |
| Immunohistochemistry analysis of paraffin-embedded rat spinal cord using KCC2 (GB113707) at dilution of 1: 1800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
