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KD-Validated SNRNP70 Rabbit mAb (20 μl)
| Reactivity: | Human, Mouse |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | small nuclear ribonucleoprotein U1 subunit 70 |
| Gene Symbol: | SNRNP70 |
| Synonyms: | RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K |
| Gene ID: | 6625 |
| UniProt ID: | P08621 |
| Clone ID: | 2W1C8 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 201-300 of SNRNP70 (NP_003080.2). |
| Dilution: | WB 1:1000-1:5000 |
| Purification Method: | Affinity purification |
| Concentration: | 1.88 mg/mL |
| Buffer: | PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SNRNP70 monoclonal antibody |
Background
Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease.
Images
 | Western blot analysis of lysates from Mouse thymus using [KD Validated] SNRNP70 Rabbit mAb (A24073) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Western blot analysis of lysates from wild type (WT) and SNRNP70 knockdown (KD) 293T cells using [KD Validated] SNRNP70 Rabbit mAb (A24073) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection:ECL Basic Kit (RM00020) Exposure time: 90s. |
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