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Anti-KLHDC1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Kelch domain-containing protein 1 |
Synonyms: | kelch domain containing 1, KLHDC1, MST025 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse KLHDC1 |
Uniprot ID: | Q80YG3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 47 kDa / 42 kDa |
Product Usage Information
WB | Rat | 1: 2000-1: 3000 | lung |
Background
Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine.
Images
| Western blot analysis of KLHDC1 (GB115190) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
