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Anti-L1CAM Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | L1CAM rabbit polyclonal antibody |
Gene Name: | Neural cell adhesion molecule L1 |
Synonyms: | NCAM-L1, CD171, L1cam, Caml1, CD171 antigen, HSAS, MASA |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse L1CAM |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 141 kDa |
Observed MW. | 220 kDa |
Uniprot ID: | P11627, Q05695 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 800 | brain, cerebral cortex, cerebellum |
Background
The protein encoded by L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of L1CAM results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
Images
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Western blot analysis of L1CAM (GB111334) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
