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| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Lamina-associated polypeptide 2, isoforms alpha/zeta |
Synonyms: | Thymopoietin isoforms alpha/zeta, TP alpha/zeta, Lap2, CMD1T, LAP2, LEMD4, PRO0868, Splenin Thymopentin, thymopoietin, TMPO, TP, TP alpha, TP5, TPRP isoform alpha |
Immunogen: | Recombinant protein corresponding to Mouse LAP2 |
Uniprot ID: | Q61033 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 75 kDa / 51/75 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, colon |
IHC/IF | Human, Mouse, Rat | 1: 300-1: 1300 | brain, colon |
Background
The nuclear lamina contains intermediate filament-type proteins called lamins that form a dense network to strengthen and stabilize the nuclear envelope. Lamina-associated polypeptide 2 (LAP2) is also known as thymopoietin. LAP2 is a nuclear envelope protein and contains an amino-terminal region called the LAP2-emerin-MAN1 or LEM motif. LAP2 also contains a unique DNA-binding amino-terminal domain. Alternative splicing produces six isoforms (α, β,γ, ε and δ) of mammalian LAP2 and three isoforms in Xenopus LAP2.
Images
| Western blot analysis of LAP2 (GB111948) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat brain using TMPO (GB111948) at dilution of 1: 650 |
| Immunohistochemistry analysis of paraffin embedded mouse brain using TMPO (GB111948) at dilution of 1: 650 |
| Immunofluorescent analysis of paraffin embedded rat brain using TMPO (GB111948) at dilution of 1: 650 |
| Immunofluorescent analysis of paraffin embedded mouse brain using TMPO (GB111948) at dilution of 1: 650 |
| Immunofluorescent analysis of paraffin embedded human colon using TMPO (GB111948) at dilution of 1: 650 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
