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| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LCAT rabbit polyclonal antibody |
Gene Name: | Phosphatidylcholine-sterol acyltransferase |
Synonyms: | Lecithin-cholesterol acyltransferase, Lcat, Phospholipid-cholesterol acyltransferase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LCAT |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: | P16301, P18424 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1:900-1:1800 | spinal cord, brain, testis |
Background
Lecithin: cholesterol acyltransferase (LCAT) is the plasma enzyme responsible for most HDL cholesteryl esters in human plasma. In species with cholesteryl ester transfer protein (CETP) it is also responsible for a significant proportion of VLDL and LDL cholesteryl esters. LCAT, through the esterification of cholesterol, plays a role in the reverse cholesterol transport pathway by facilitating the net movement of cholesterol from peripheral tissues back to the liver for excretion. LCAT deficiency results in low levels of plasma HDL, whereas a transgenic over expression of LCAT results in increased plasma HDL concentrations.
Images
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Immunohistochemistry of paraffin embedded mouse brain using LCAT (GB111159) at dilution of 1:900 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spinal cord using LCAT (GB111159) at dilution of 1:900 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using LCAT (GB111159) at dilution of 1:900 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat spinal cord using LCAT (GB111159) at dilution of 1:900 (400x lens) |
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Immunohistochemistry of paraffin embedded rat testis using LCAT (GB111159) at dilution of 1:900 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
