Your shopping cart is empty!
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | LEF1 rabbit polyclonal |
Gene Name: | Lymphoid enhancer-binding factor 1 |
Synonyms: | LEF-1, Lef1, TCF1 alpha, TCF1ALPHA, TCF7L3, FLJ46390, TCF10, LEF1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LEF1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 900-1: 1800 | thymus |
IF | Mouse, Rat | 1: 600-1: 1200 | thymus, spleen |
Background
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse thymus using LEF1 (GB111887) at dilution of 1: 1800 |
| Immunohistochemistry analysis of paraffin-embedded rat thymus using LEF1 (GB111887) at dilution of 1: 1800 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse spleen using LEF1 (GB111887) at dilution of 1: 1200 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse thymus using LEF1 (GB111887) at dilution of 1: 1200 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat thymus using LEF1 (GB111887) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
