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Anti-LIN7B Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Protein lin-7 homolog B |
Synonyms: | hLin7B, hVeli2, lin 7 homolog B (C. elegans), LIN 7B, LIN7B, MALS 2, MALS2, Mammalian lin seven protein 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse LIN7B |
Uniprot ID: | O88951 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 23 kDa / 23 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 2000-1: 3000 | brain, kidney |
Background
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules . This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface.
Images
| Western blot analysis of LIN7B (GB114300) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
