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| Reactivity: | M & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Lymphocyte antigen 6C1 (Ly-6C1) |
Synonyms: | Ly 6c, Ly6c protein, Ly-6C, Ly6c1, Ly6c2, Lymphocyte antigen 6C, Lymphocyte antigen 6C1, Lymphocyte antigen 6C2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to mouse LY6C |
Uniprot ID: | P0CW02 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 14 kDa / 14 kDa |
Product Usage Information
WB | Mouse | 1: 5000-1: 30000 | spleen, lung, lymph node |
IHC/IF | Mouse | 1: 800-1: 1600 | spleen, lung |
Background
Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. It is a member of the Ly6 multigene family of type V glycophosphatidylinositol anchored cell surface proteins. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T cell subsets. Mice with the Ly6.2 allotype (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have subsets of CD4+Ly6C+ and CD8+Ly6C+ cells, while Ly6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have only CD8+Ly6C+ lymphocytes.
Images
| Western blot analysis of LY6C (GB115601) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded spleen of mouse nflammatory model induced by LPS(6h) using LY6C (GB115601) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded lung of mouse Inflammatory model induced by LPS(6h) using LY6C (GB115601) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
