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Anti-Lamin A + Lamin C Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Lamin A + Lamin C rabbit polyclonal antibody |
Gene Name: | Prelamin-A/C |
Synonyms: | Lamin-A/C, Lmna, Lmn1, Cardiomyopathy dilated 1A (autosomal dominant), LGMD1B, LFP, LMNA, Renal carcinoma antigen NYREN32 |
Immunogen: | Recombinant protein corresponding to Mouse Lamin A + Lamin C |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 74 kDa |
Observed MW. | 74 kDa |
Uniprot ID: | P48678 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 500-1: 1000 | liver, colon |
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Images
 | Western blot analysis of LaminAC (GB112400) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
