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Anti-Lamin A + Lamin C Mouse mAb (100 μl)
| Reactivity: | H,M,R & H,R |
| Applications: | WB & IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Prelamin-A/C |
Synonyms: | Lamin-A/C, Lmna, Lmn1, Cardiomyopathy dilated 1A (autosomal dominant), LGMD1B, LFP, LMNA, Renal carcinoma antigen NYREN32 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Lamin A + Lamin C |
Uniprot ID: | P48678 |
Isotype: | IgG2b,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 74 kDa / 74 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | lung |
IHC/IF | Human, Rat | 1: 1500-1: 3000 | cervical cancer, liver |
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants.
Images
| Western blot analysis of Lamin A/C (GB122400) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded human cervical cancer using Lamin A/C (GB122400) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded human lung cancer using Lamin A/C (GB122400) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using Lamin A/C (GB122400) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse liver using Lamin A/C (GB122400) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded rat liver using Lamin A/C (GB122400) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
