Your shopping cart is empty!
Anti-Legumain Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Legumain rabbit polyclonal antibody |
Gene Name: | Legumain |
Synonyms: | Asparaginyl endopeptidase, Protease, cysteine 1, Lgmn, Prsc1, AEP, Cysteine protease 1 |
Immunogen: | Recombinant protein corresponding to Mouse Legumain |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Lysosome |
Uniprot ID: | O89017, Q9R0J8 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 100-1: 600 | kidney |
Background
LGMN (Legumain), also known as asparaginyl endopeptidase or AEP, is a broadly expressed lysosomal cysteine endopeptidase that belongs to peptidase family C13 and specifcally hydrolyzes substrate asparaginyl bonds . LGMN directly regulates diverse physiological and pathological processes by remodeling tissue-specific targets . In addition, LGMN indirectly contributes to atherosclerotic plaque instability through activation of cathepsin L in the arterial ECM . LGMN is secreted as inactive prolegumain (56 kDa) and processed into enzymatically active 46 and 36 kDa forms, as well as a 17 kDa enzymatically inactive C-terminal fragment.
Images
| Immunohistochemistry of paraffin embedded mouse kidney using Legumain (GB111780) at dilution of 1:300 (300x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using Legumain (GB111780) at dilution of 1:300 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
