Your shopping cart is empty!
Anti-Lrp2 / Megalin Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Lrp2 / Megalin rabbit polyclonal antibody |
Gene Name: | Low-density lipoprotein receptor-related protein 2 |
Synonyms: | LRP-2, Glycoprotein 330, gp330, Megalin, Lrp2, Calcium sensor protein, DBS |
Immunogen: | Recombinant protein corresponding to Mouse Lrp2 / Megalin |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Uniprot ID: | A2ARV4, P98158 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | kidney |
Background
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones.
Images
| Immunohistochemistry of paraffin embedded mouse kidney using Megalin (GB112109) at dilution of 1:1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using Megalin (GB112109) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
