Your shopping cart is empty!
| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MDA5 rabbit polyclonal |
Gene Name: | Interferon-induced helicase C domain-containing protein 1 |
Synonyms: | Helicase with 2 CARD domains, Helicard, Melanoma differentiation-associated protein 5, MDA-5, RIG-I-like receptor 2, RLR-2, Ifih1, RH116, MDA5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MDA5 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
IHC/IF | Mouse | 1: 300-1: 600 | heart, kidney, liver |
Background
IFIH1 (Interferon-induced helicase C domain-containing protein 1) is a putative RNA helicase that is upregulated in response to treatment with IFNB or IFNB and MEZ. It is also named as MDA5 and RH116. Ectopic expression of MDA5 in melanoma cells resulted in reduced colony formation, suggesting an interaction of the CARD and apoptotic signal molecules. Functional analysis indicated that MDA5 is an RNA-dependent ATPase. IFIH1 has an apparent molecular mass of 117-130 kDa, and always other bands (70 kDa and 90 kDa) can be detected as cleaved products.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse liver using MDA5 (GB111891) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using MDA5 (GB111891) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using MDA5 (GB111891) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using MDA5 (GB111891) at dilution of 1: 600 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse kidney longitudinal using MDA5 (GB111891) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
