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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Dual specificity mitogen-activated protein kinase kinase 1 |
Synonyms: | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1, mitogen activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1 |
Immunogen: | Recombinant protein corresponding to Mouse MEK1 |
Uniprot ID: | P31938 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus, Membrane |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 3000 | brain, kidney, liver cancer, lung, lung cancer, testis |
Background
The protein is a member of the dual-specificity protein kinase family that acts as amitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Images
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Immunohistochemistry of paraffin embedded human liver cancer using MEK (GB11601) at dilution of 1:1500 (400x lens) |
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Immunohistochemistry of paraffin embedded human lung cancer using MEK (GB11601) at dilution of 1:1500 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse kidney using MEK (GB11601) at dilution of 1:1500 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using MEK (GB11601) at dilution of 1:1500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using MEK (GB11601) at dilution of 1:1500 (400x lens) |
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Immunofluorescence of paraffin embedded mouse testis using MEK (GB11601) at dilution of 1:1500 (300x lens) |
 | Immunofluorescence of paraffin embedded mouse brain using MEK (GB11601) at dilution of 1:1500 (400x lens) |
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Immunofluorescence of paraffin embedded mouse lung using MEK (GB11601) at dilution of 1:1500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
