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| Reactivity: | H |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MIIP rabbit polyclonal |
Gene Name: | Migration and invasion-inhibitory protein |
Synonyms: | Invasion-inhibitory protein 45, IIp45, Miip, D4Wsu114e, Iip45, IGFBP2 binding protein |
Immunogen: | Recombinant protein corresponding to Mouse MIIP |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 600-1: 1200 | colon cancer, esophageal cancer |
Background
MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression.
Images
| Immunohistochemistry analysis of paraffin-embedded human colon cancer using MIIP (GB113045) at dilution of 1: 1200 |
| Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using MIIP (GB113045) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
