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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MOG rabbit polyclonal |
Gene Name: | Ran guanine nucleotide release factor |
Synonyms: | MOG1, MOG 1, MOG1 homolog, Ran guanine nucleotide release factor, Ran-binding protein MOG1, RanGNRF, RANGRF, MOG |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MOG |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 3000 | testis |
IF | Mouse, Rat | 1: 500-1: 1500 | testis |
Background
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse tumor using MOG (GB11850) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded mouse tumor using MOG (GB11850) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
