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Anti-MPRIP Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MPRIP rabbit polyclonal antibody |
Gene Name: | Myosin phosphatase Rho-interacting protein |
Synonyms: | Rho-interacting protein 3, RIP3, p116Rip, Kiaa0864, Rhoip3, Mrip, RP23-180B18.4, p116 Rho-interacting protein |
Immunogen: | Recombinantproteincorrespondingto Mouse MPRIP |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 116 kDa |
Observed MW. | 130 kDa |
Uniprot ID: | Q6WCQ1, P97434, Q9ERE6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | testis, lung, ovary |
Background
MPRIP, also named as KIAA0864, MRIP, RHOIP3 and p116Rip, is required for the regulation of the actin cytoskeleton by RhoA and ROCK1. MRPIP targets myosin phosphatase to the actin cytoskeleton. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. The antibody recognizes the C-term of isoform2 and isoform3 of MPRIP.
Images
| Western blot analysis of MRIP (GB111658) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
