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Anti-MTHFD1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | C-1-tetrahydrofolate synthase, cytoplasmic |
Synonyms: | C1-THF synthase, Mthfd1, C1TC, MTHFD, Cytoplasmic C 1 tetrahydrofolate synthase, Methylenetetrahydrofolate dehydrogenase |
Immunogen: | Recombinant protein corresponding to Mouse MTHFD1 |
Uniprot ID: | Q922D8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. / Observed MW. | 101 kDa / 101 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000--1: 2000 | kidney, liver |
IHC/IF | Human | 1: 500-1: 1400 | colon, liver cancer, liver |
Background
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses.
Images
| Western blot analysis of MTHFD1 (GB112031) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human colon using MTHFD1 (GB112031) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using MTHFD1 (GB112031) at dilution of 1: 700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
