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Anti-MUC1/CD227 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Mucin-1 |
Synonyms: | ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM, PEMT, Episialin, EAM, CA 15-3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CD227 |
Uniprot ID: | P15941 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm |
Predicted MW. / Observed MW. | 122 kDa / 180-300 kDa |
Product Usage Information
WB | Human | 1: 300-1: 600 | DU 145 |
IHC/IF | Human | 1: 500-1: 1000 | endometrial cancer, breast cancer, kidney |
Background
Mucin 1 (MUC1 [CD227]) is a type I membrane-tethered glycopro tein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aber rantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans.MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling.
Images
| Western blot analysis of MUC1 (GB115321) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded human endometrial cancer using CD227 (GB115321) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using CD227 (GB115321) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human kidney using CD227 (GB115321) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
