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Anti-Matrin 3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Matrin-3 |
Synonyms: | KIAA0723, MATR3, matrin 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Matrin 3 |
Uniprot ID: | Q8K310 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 95 kDa / 130 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 3000 | colon, liver, brain |
IHC/IF | Human, Mouse, Rat | 1: 1500-1: 3000 | lung cancer, testis |
Background
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs (By similarity). {ECO:0000250}.; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins (By similarity).
Images
| Western blot analysis of Matrin 3 (GB114298) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using Matrin 3 (GB114298) at dilution of 1: 3000 |
| Immunofluorescence analysis of paraffin embedded mouse testis using Matrin 3 (GB114298) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
