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Anti-Metabotropic Glutamate Receptor 4/MGLUR4 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Metabotropic Glutamate Receptor 4/MGLUR4 rabbit polyclonal antibody |
Gene Name: | Metabotropic glutamate receptor 4 |
Synonyms: | Glutamate receptor metabotropic 4, GPRC1D, Grm4, Metabotropic glutamate receptor 4, mGluR4, mGlu4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Metabotropic Glutamate Receptor 4/MGLUR4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Uniprot ID: | Q68EF4 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 1000-1: 2000 | striatum, brain |
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
Images
| Immunohistochemistry of paraffin embedded mouse striatum using GRM4 (GB113895) at dilution of 1: 2000 (200x lens |
| Immunohistochemistry of paraffin embedded rat brain using GRM4 (GB113895) at dilution of 1: 1500 (200x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
