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Anti-Munc13-1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Munc13-1 rabbit polyclonal antibody |
Gene Name: | Protein unc-13 homolog A |
Synonyms: | Unc13a, UNC13A, Munc13-1, unc-13 homolog A (C. elegans), unc-13 homolog A, KIAA1032, Munc 13, Protein unc-13 homolog A, UN13A, Unc13h1 |
Immunogen: | Recombinant protein corresponding to Mouse Munc13-1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 194 kDa |
Observed MW. | 194 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 1000-1: 2000 | neonatal brain |
Background
Unc-13 homolog A (C. elegans) is a protein that in humans is encoded by the UNC13A gene.. This gene encodes a member of the UNC13 family. UNC13A plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool. It is particularly important in most glutamatergic-mediated synapses but not GABA-mediated synapses. It plays a role in dendrite formation by melanocytes and in secretory granule priming in insulin secretion.
Images
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Western blot analysis of munc-13a (GB11679) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
