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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Myeloid differentiation primary response protein MyD88 |
Synonyms: | MYD88, MYD88D, myeloid differentiation primary response 88 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MYD88 |
Uniprot ID: | P22366 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 100-1: 400 | heart, kidney, colon |
Background
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS).
Images
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Immunohistochemistry analysis of paraffin-embedded rat kidney using MyD88 (GB11269) at dilution of 1: 200 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using MyD88 (GB11269) at dilution of 1: 200 |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using MyD88 (GB11269) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using MyD88 (GB11269) at dilution of 1: 200 |
| Immunofluorescence analysis of paraffin embedded mouse heart using MYD88 (GB11269) at dilution of 1: 200 |
| Immunofluorescence analysis of paraffin embedded mouse kidney using MYD88 (GB11269) at dilution of 1: 200 |
| Immunofluorescence analysis of paraffin embedded rat brain using MYD88 (GB11269) at dilution of 1: 200 |
| Immunofluorescence analysis of paraffin embedded rat colon using MYD88 (GB11269) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
