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Anti-NEIL1 Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NEIL1 rabbit polyclonal antibody |
Gene Name: | Endonuclease 8-like 1 |
Synonyms: | DNA glycosylase/AP lyase Neil1, DNA-(apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, Nei homolog 1, NEH1, Nei-like protein 1, Neil1, Nei1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NEIL1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cytoskeleton, Nucleus |
Predicted MW. | 44 kDa |
Observed MW. | 44 kDa |
Uniprot ID: | Q8K4Q6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 800-1: 1600 | liver, lymph node |
IHC/IF | Human, Mouse, Rat | 1: 300-1: 3000 | colon, esophagus, esophagus cancer, heart, placenta, spleen |
Background
NEIL1, also named as NEH1 and FPG1, belongs to the FPG family. It is involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. NEIL1 acts as DNA glycosylase that recognizes and removes damaged bases. It has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. NEIL1 has marginal activity towards 8-oxoguanine. It has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.
Images
| Western blot analysis of Neil1 (GB112581) at dilution of 1: 800 |
| Immunohistochemistry of paraffin embedded mouse colon using Neil1 (GB112581) at dilution of 1: 1200 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse heart using Neil1 (GB112581) at dilution of 1: 1200 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse spleen using Neil1 (GB112581) at dilution of 1: 1200 (400x lens) |
| Immunofluorescence of paraffin embedded human esophagus cancer using Neil1 (GB112581) at dilution of 1: 300 (400x lens) |
| Immunofluorescence of paraffin embedded human placenta using Neil1 (GB112581) at dilution of 1: 300 (400x lens) |
| Immunofluorescence of paraffin embedded mouse esophagus using Neil1 (GB112581) at dilution of 1: 300 (400x lens) |
| Immunofluorescence of paraffin embedded mouse placenta using Neil1 (GB112581) at dilution of 1: 300 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
