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Anti-NF2 / Merlin Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NF2 rabbit polyclonal antibody |
Gene Name: | Merlin |
Synonyms: | Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomin, Schwannomin, NF2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NF2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cell Membrane, Nucleus |
Uniprot ID: | P46662, Q63648 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 3000 | brain, eye, heart, lung, spleen |
Background
NF2 is the probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.
Images
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Immunohistochemistry of paraffin embedded mouse eye using NF2 (GB111285) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse heart using NF2 (GB111285) at dilution of 1:2000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spleen using NF2 (GB111285) at dilution of 1:2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat heart using NF2 (GB111285) at dilution of 1:2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using NF2 (GB111285) at dilution of 1:2000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse brain using NF2 (GB111285) at dilution of 1:2000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse spleen using NF2 (GB111285) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded rat lung using NF2 (GB111285) at dilution of 1:2000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
