Your shopping cart is empty!
Anti-NOTCH4 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NOTCH4 rabbit polyclonal antibody |
Gene Name: | Neurogenic locus notch homolog protein 4 |
Synonyms: | Notch 4, hNotch4, INT3, Notch 4 extracellular truncation, Notch 4 intracellular domain |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NOTCH4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Nucleus |
Uniprot ID: | Q99466 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 600-1: 1200 | colon cancer, esophagus, liver, lung cancer |
Background
Notch4 is a member of the Notch family. The Notch4 signaling network is an evolutionarily conserved intracellular pathway that regulates physical cell to cell interactions. The Notch4 protein, once cleaved from the trans-Golgi network, is presented on the cell surface as a heterodimer. Notch4 regulates cell-fate determination as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1. In Drosophila, once these ligands are activated via the release of the notch intracellular domain (NICD), Notch4 forms a transcriptional activator complex with RBPJ/RBPSUH which then activates the genes of the Enhancer of Split (E(spl)) locus. Notch4 also plays a role in vascular, renal and hepatic development, the implementation of differentiation, proliferation and apoptotic programs, and the regulation of branching morphogenesis in the development of the vascular system.
Images
|
|
Immunohistochemistry of paraffin embedded human colon cancer using Notch4 (GB111311) at dilution of 1:600 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded human esophagus using Notch4 (GB111311) at dilution of 1:600 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded human liver using Notch4 (GB111311) at dilution of 1:600 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded human lung cancer using Notch4 (GB111311) at dilution of 1:600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |